Principles of Early Stopping of Randomized Trials for Efficacy: A Critique of Equipoise and an Alternative Nonexploitation Ethical Framework

, Recent controversial decisions to terminate several large clinical trials have called attention to the need for developing a sound ethical framework to determine when trials should be stopped in light of emerging efficacy data. Currently, the fundamental rationale for stopping trials early is base...

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Bibliographic Details
Authors: Buchanan, David (Author) ; Miller, Franklin G (Author)
Format: Electronic Article
Language:English
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Published: Johns Hopkins Univ. Press 2005
In: Kennedy Institute of Ethics journal
Year: 2005, Volume: 15, Issue: 2, Pages: 161-178
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