Informed consent for early-phase clinical trials: therapeutic misestimation, unrealistic optimism and appreciation

Unrealistic therapeutic beliefs are very common—the majority of patient-subjects (up to 94%) enrol in phase 1 trials seeking and expecting significant medical benefit, even though the likelihood of such benefit has historically proven very low. The high prevalence of therapeutic misestimation and un...

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Bibliographic Details
Authors: Halpern, Jodi (Author) ; Paolo, David (Author) ; Huang, Andrew (Author)
Format: Electronic Article
Language:English
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Published: BMJ Publ. 2019
In: Journal of medical ethics
Year: 2019, Volume: 45, Issue: 6, Pages: 384-387
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