A randomised controlled trial of ribavirin in Crimean Congo haemorrhagic fever: ethical considerations
The randomised controlled trial (RCT) constitutes a quantitative, comparative, controlled study of a particular treatment, and provides invaluable evidence regarding its pharmacotherapeutic efficacy. These studies are generally predicated upon the ethical principle of clinical equipoise. However, th...
| Authors: | ; ; |
|---|---|
| Format: | Electronic Article |
| Language: | English |
| Check availability: | HBZ Gateway |
| Journals Online & Print: | Drawer...
|
| Fernleihe: | Fernleihe für die Fachinformationsdienste |
| Published: |
BMJ Publ.
2012
|
| In: |
Journal of medical ethics
Year: 2012, Volume: 38, Issue: 2, Pages: 117-120 |
| Online Access: |
Volltext (JSTOR) Volltext (lizenzpflichtig) Volltext (lizenzpflichtig) |
MARC
| LEADER | 00000caa a22000002 4500 | ||
|---|---|---|---|
| 001 | 1816143006 | ||
| 003 | DE-627 | ||
| 005 | 20230427161302.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220908s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/medethics-2011-100107 |2 doi | |
| 035 | |a (DE-627)1816143006 | ||
| 035 | |a (DE-599)KXP1816143006 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 1 |2 ssgn | ||
| 100 | 1 | |a Arda, B. |e VerfasserIn |4 aut | |
| 245 | 1 | 2 | |a A randomised controlled trial of ribavirin in Crimean Congo haemorrhagic fever: ethical considerations |
| 264 | 1 | |c 2012 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a The randomised controlled trial (RCT) constitutes a quantitative, comparative, controlled study of a particular treatment, and provides invaluable evidence regarding its pharmacotherapeutic efficacy. These studies are generally predicated upon the ethical principle of clinical equipoise. However, this may be insufficient to justify withholding treatment from a control group while assessing drug therapy in a potentially fatal disease. Thus, the criteria for randomisation, informed consent methodology and timing, and consideration of treatment options in such a scenario remain the province of medical ethics. This paper addresses the need for an RCT of ribavirin in the treatment of Crimean Congo haemorrhagic fever, and highlights underlying ethical concerns in light of the current medical, virological and ethical literature. | ||
| 601 | |a Controlling | ||
| 700 | 1 | |a Aciduman, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Johnston, J. C. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of medical ethics |d London : BMJ Publ., 1975 |g 38(2012), 2, Seite 117-120 |h Online-Ressource |w (DE-627)323607802 |w (DE-600)2026397-1 |w (DE-576)260773972 |x 1473-4257 |7 nnns |
| 773 | 1 | 8 | |g volume:38 |g year:2012 |g number:2 |g pages:117-120 |
| 856 | |3 Volltext |u http://www.jstor.org/stable/23215413 |x JSTOR | ||
| 856 | 4 | 0 | |u https://doi.org/10.1136/medethics-2011-100107 |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://jme.bmj.com/content/38/2/117.abstract |x Verlag |z lizenzpflichtig |3 Volltext |
| 935 | |a mteo | ||
| 951 | |a AR | ||
| ELC | |a 1 | ||
| ITA | |a 1 |t 1 | ||
| LOK | |0 000 xxxxxcx a22 zn 4500 | ||
| LOK | |0 001 4185596898 | ||
| LOK | |0 003 DE-627 | ||
| LOK | |0 004 1816143006 | ||
| LOK | |0 005 20220908053547 | ||
| LOK | |0 008 220908||||||||||||||||ger||||||| | ||
| LOK | |0 035 |a (DE-Tue135)IxTheo#2022-08-03#97286B8F59241250B8E700D9D29D179BDA375C72 | ||
| LOK | |0 040 |a DE-Tue135 |c DE-627 |d DE-Tue135 | ||
| LOK | |0 092 |o n | ||
| LOK | |0 852 |a DE-Tue135 | ||
| LOK | |0 852 1 |9 00 | ||
| LOK | |0 866 |x JSTOR#http://www.jstor.org/stable/23215413 | ||
| LOK | |0 935 |a ixzs |a ixrk |a zota | ||
| OAS | |a 1 |b inherited from superior work | ||
| ORI | |a SA-MARC-ixtheoa001.raw | ||