What determines whether patients are willing to participate in resuscitation studies requiring exception from informed consent?
Objectives: To examine the willingness of patients to participate in a resuscitation study that requires exception from informed consent and to determine if willingness to participate is associated with demographic and other characteristics. Methods: Adult patients in an emergency department and in...
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| Format: | Electronic Article |
| Language: | English |
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| Published: |
BMJ Publ.
2006
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| In: |
Journal of medical ethics
Year: 2006, Volume: 32, Issue: 8, Pages: 468-472 |
| Online Access: |
Presumably Free Access Volltext (JSTOR) Volltext (lizenzpflichtig) Volltext (lizenzpflichtig) |
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| 245 | 1 | 0 | |a What determines whether patients are willing to participate in resuscitation studies requiring exception from informed consent? |
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| 520 | |a Objectives: To examine the willingness of patients to participate in a resuscitation study that requires exception from informed consent and to determine if willingness to participate is associated with demographic and other characteristics. Methods: Adult patients in an emergency department and in a geriatric outpatient clinic were surveyed. Patients were asked to imagine that they presented to an emergency department with cardiac arrest and asked about their willingness to (1) receive a new drug outside of a study, (2) receive a new drug as part of a study and (3) participate in a randomised controlled trial (RCT) for a new drug. Patients were also asked about participation in studies of invasive procedures. Results: 213 patients from a geriatric clinic and 207 from an emergency department were surveyed. Two thirds of patients from the geriatric clinic and 83% from the emergency department were willing to receive an experimental drug outside of a study. Patients were less willing to participate in a study of the new drug and even less likely to participate in an RCT for the new drug (χ2 test for trend, p<0.001 for both settings). Patients were less likely to participate in a study of thoracotomy than in a study that required placement of a femoral catheter (p = 0.008 for the geriatric clinic, p = 0.01 for the emergency department). Willingness to participate was not associated with trust in the doctors. Conclusions: Study design and invasiveness of the intervention were associated with the willingness of patients to participate in resuscitation studies that require exception from informed consent. | ||
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| 700 | 1 | |a Al-Marshad, A. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lowenstein, S. R. |e VerfasserIn |4 aut | |
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